Acromegaly (hereinafter referred to as acromegaly) is a chronic progressive endocrine disease with insidious onset, and the course of the disease may be several years or even more than 10 years when the patient sees a doctor. The main cause of large limbs is the excess production of growth hormone (GH) in the body. More than 95% of patients with large limbs are caused by GH-secreting pituitary adenomas. Long-term excessive secretion of GH can lead to excessive hyperplasia of soft tissue, bone and cartilage in the whole body, resulting in facial changes, hypertrophy of hands and feet, thick skin, enlarged viscera, bone and joint lesions, and sleep apnea syndrome. In addition, the incidence of malignant tumors such as pituitary tumor compression symptoms, diabetes, hypertension, cardiovascular and cerebrovascular diseases, respiratory diseases and colon cancer will also increase accordingly. These metabolic disorders and complications seriously affect patients' health and quality of life, resulting in patients' life span shortened. Clinical delays in diagnosis and treatment can significantly increase the incidence of these complications.
