2026年 · 第106卷第38期

In the article "Clinical Practice Guidelines for Perioperative Fluid Therapy for Adult Patients in China (2025 Edition)" published in the Chinese Medical Journal on January 14, 2025, Vol. 105, No. 2, the lower right corner of page 132, where "HCTf is preoperative/pre-blood loss hematocrit" should read "HCTf is postoperative/pre-blood loss hematocrit", this correction is hereby made.

In hypertensive patients, long-term maintenance of systolic blood pressure within established target ranges is associated with a significantly reduced risk of chronic kidney disease. A recent post-hoc analysis based on the STEP study showed that the "time-in-target range" (TTR) of systolic blood pressure is expected to become an important treatment goal and quality evaluation indicator in the management of hypertension.

Colorectal cancer is one of the most common malignant tumors of the gastrointestinal tract. Because its early symptoms are not obvious, it often leads to delayed diagnosis and seriously affects the prognosis of patients. Improving the ability to identify high-risk groups early is the key to improving the survival rate of colorectal cancer. In recent years, DNA methylation, as a stable epigenetic modification closely related to tumorigenesis, has increasingly become an important research direction in the field of early cancer screening. In particular, the DNA methylation state of leukocytes is affected by the tumor microenvironment and immune response, and has the potential to reflect tumor changes in the body. Against this backdrop, the research team systematically screened peripheral blood leukocyte DNA methylation markers based on population screening cohorts and constructed a colorectal tumor risk prediction model, aiming to provide a scientific basis for individualized screening strategies.