Volume 106 ·  Issue 13 ·  2026

Interleukin-1 (IL-1) plays a core role in the pathogenesis of autoimmune inflammatory diseases (AIID). Blocking the inflammatory cascade driven by IL-1 has become a critical strategy for the treatment of various AIID. Since IL-1 inhibitors were approved on the market in China on October 2023, they have attracted great attention in clinical practice and have been increasingly used in clinical settings. In order to reduce the clinical uncertainties and potential risks that may be brought about by off-label drug use, the Rheumatology and Immunology Professional Committee of the China Primary Health Care Foundation organized experts from multiple disciplines to focus on 12 clinical issues regarding the treatment of AIID with IL-1 inhibitors. Based on the latest evidence-based medical evidence and China′s national conditions, fourteen recommendations on crystal-induced arthropathies, autoinflammatory syndrome and periodic fever syndrome have been formulated, aiming to standardize the clinical application and pharmaceutical management of IL-1 inhibitors in China.

To standardize dural closure techniques and material selection in neurosurgery and reduce the incidence of postoperative complications such as cerebrospinal fluid leakage, led by the Neurosurgery Branch of the Chinese Medical Association, domestic experts in neurosurgery and related fields were organized to follow the principles of evidence-based medicine and grading of recommendations assessment, development and evaluation (GRADE) system. The consensus was formulated based on a systematic review of high-quality international evidence combined with clinical practice in China. The consensus underscores the pivotal role of achieving "Watertight Dural Closure (WTDC)" and establishes a stepwise material selection strategy: prioritizing autologous tissue as the primary choice, supplemented by dural patches, and reinforced by dural sealants. For the first time, this consensus introduces a four-type morphological classification for dural incisions (Types Ⅰ-Ⅳ) and a five-grade classification for dural closure integrity (Grades A-E), upon which a quantitative risk assessment system has been established. Addressing key clinical issues, including repair material characteristics, technique application based on incision types and closure grades, site-specific repair strategies for different anatomical locations, management of special populations, and postoperative outcome evaluation, the Consensus formulates a total of 19 recommendations, aiming to provide a systematic and standardized clinical decision-making framework and operational guidance for dural repair in neurosurgery.

To evaluate the efficacy of the endotherapy rob-assistant (ERA) system in treating gastrointestinal polyps in beagle dogs.

Sixteen beagle dogs, aged 10-20 months and weighing 8-15 kg, were enrolled. They were randomly divided into an experimental group (ERA-assisted, n=8) and a control group (assisted by an instrument nurse, n=8) using a random number table. Artificial polyps were created in the gastric antrum, gastric body, gastric fundus, and colon using high-frequency electrocoagulation marking. Endoscopic mucosal biopsy and endoscopic mucosal resection were then performed. Procedural success rate, operation time, and complications were compared between the groups. Wound healing was assessed two weeks postoperatively.

All the artificial polyp models were successfully established, success rate: 100% (16/16). All procedures were completed without intraoperative complications, and postoperative wound healing was favorable. Compared with the control group, the experimental group showed no statistically significant difference in EMR operation time[M (Q₁, Q₃)] [344 (330, 388) vs 372 (330, 422) s, P>0.05]. Both the instrument transfer time [upper endoscopy: 9 (8, 9) vs 10 (8, 13) s; colonoscopy: 8 (8, 9) vs 11 (10, 13) s, all P<0.05] and the biopsy operation time [upper endoscopy: 67 (53, 79) vs 79 (73, 87) s; colonoscopy: 64 (51, 72) vs 77 (71, 81) s, all P<0.05] were significantly shorter in the experimental group, compared to the control group. Furthermore, the incidence of risky maneuvers was significantly lower than that of the control group [43% (100/233) vs 0, P<0.05].

The ERA system is safe and effective for treating gastrointestinal polyps in beagle dogs.

Chinese Medical Journal, September 16, 2025, Volume 105, Issue 35, "Clinical Features and Prognostic Analysis of Basal Ganglia Cerebral Infarction Complicated with Basal Ganglia Calcification in Children after Minor Trauma", page 3088, Figure 1M, N, O The red arrows in the three pictures are in wrong position, and the arrows should point to high-density shadows in the basal ganglia region. Corrections are hereby made.